I am very worried I called the vet they said oops sorry they made a mistake. I check this thread regularly and Im sooo grateful to all who wrote. Decreased conscious proprioception. I am so angry. 5 hours after the dose she's home resting. Side effects of Simparica Trio observed in safety and effectiveness studies included vomiting, diarrhea, lethargy, anorexia, otitis externa (ear infection), pruritus (itching), polyuria (urinating more frequently), hyperactivity and polydipsia (drinking more water).. Is Simparica Trio killing dogs? Gave my 14 month old 88 lb. Head down, facing the wall, tremors, lethargic, and she can't seem to see well. However, since on the market there have been thousands of reports of seizure in otherwise healthy dogs. Simparica and Simparica Trio should be stored at or below 86 F. Brief exposure of Simparica to temperatures up to 104 F are acceptable. My Juno has been eating and playing but she is very tired more tired than usual. She has good days and bad days but she is far from the dog she use to be. He also got that odd cough here and there that I read someone else mention. We are already close to $2000 in Vet bills not counting the poison we bought her. Dogs with existing heartworm infections should be treated to remove the adult heartworms before going back on this medication. Contact your vet if your dog misses a month or more of heartworm preventionyour dog might have become infected with heartworm larvae. My sweet, funny, smart as can be baby girl died on 9/26/20. Thank you all so much!!!! Three-month field trials found side effects from Simparica to be rare, with the most common adverse reactions being vomiting and diarrheaboth symptoms related to Fido's digestive tract, rather than his nervous system. Product Information: Simparica Trio (sarolaner, moxidectin, and pyrantel) Chewables are a safe monthly chewable for dogs that prevents heartworm disease, kills adult fleas and is indicated for the treatment and prevention flea infestations, the treatment and control of tick infestations, and the treatment and control of roundworms and . They must get some kind of monetary bonus for only selling Simparica. Will be talking to the vet inregards to his side effects. She has been treated by this clinic since birth. Dr said either Simparica (best case scenario), GOLPP or brain tumor. She's not drinking water or eating all she wants to do is sleep. We have spent well over $5000.00 and upset about all the horror stories we are now hearing. Thank you. I took him back to the vet and explained my concern that it was from the Simparica Trio and they didn't seem concerned that it was the issue. Oh Lord, back to finding another vet. Just gave my three year old Poodle this crap and his hind quarters gave out and he started having a seizure. You ask why they are giving this poison to our furbabies, it's easy. 8 months of prednisone and around the clock nursing care at home saved her life. They want to test him for the MDR gene, put him on fluids and I have to take him in tomorrow for more fluids but he is not improving. Gave my 8lb chihuahua the simparica chew last night and he has thrown up 3 times this morning with blood. I'm so angry this medication is on the market. Tasty, liver-flavored chewable tablet is easy to administer. Any tips on how to flush it from her system ? Those jaw spasms have decreased but were pretty alarming in Dec and January. For the first time in 12 years my dog has 6-7 large kidney stones which will require surgery. Maybe dont have a dog. I dont know whether its a coincidence or not, but 4 days after second dose of Simparica Trio, my dog ended up at an urgent care with blood in his urine. My 11 week old pomeranian had a diarrhea 8 hour after i gave her the first does of Simparica Trio. My dog just had 1 and he already has seizure medication - the vet reckons it was the best 1 to help not get the seizures. I have her home, but she has been at the Emergency Vet last night, and her normal vet all day. No simparica for them either! I gave this for the first time to my hound and about 3 hours later, she was very unsteady on her feet, eyes half shut and then had 4 episodes of breathing rapidly that each lasted 30 seconds or so and all happened within a 30 minute period. The representative for the company says the half life is 16 days. Those with Diarrhea symptom, did it look like mucus in their pets stool? Sorry to hear about this happening to so many. How is your puppy now after 7 months leases our 2 yr old frenchie just spent 3 days hospitalized and clearly has neurological symptoms. Still waiting to find out of she has progressed. Today really soft stool (not diarrhea but close). Our golden retriever had his first seizure after taking Simparica Trio last October. Simparica chewable is a preventative that is better suited to healthy adult dogs living in areas where ticks are prevalent. Seizures continue and its Monday. This morning (12/19/21) was a bit better, still hesitant on the steps but we didnt experience any loss of appetite and was eager to go outside (still some diarrhea though). In clinical trials, vomiting and diarrhea were the most frequently reported adverse reactions. Hi Laura, How is you pup doing one after getting off simparica? But now I tell everyone just be aware that this product does have the potential to cause neurological harm. Thank you in advance. I have been giving my lab puppy (6 months old now) Simparica Trio since October. I also changed him over to a raw diet a few weeks ago too have taken him off of this again to see if raw diet is causing it. My wife and I didn't understand why. Company asked us to do diagnostic testing at vet. Many people have reported this as only temporary. oh I should mention shadow is our 8 yr old dogue de Bordeaux - he has never had a reaction to anything ever before in his life and has never needed a vet so this was not usual at all for him .. My beautiful Golden was switched from her previous Medicine to this one. Side effects are rare and may include: Vomiting Lethargy Diarrhea Loss of appetite Neurologic side effects have been seen after using medications in this class of drugs. Oh how I wish I had know the side effects of this medicine I would never haven given it to her.. the company that makes this poison should be sued. First dose was on 4/1 and 9 days later he was vomiting goop (yellow thick goo), he would drink water and vomit. I have an appointment this Wednesday but not sure if Im going to keep it if the cough will go away eventually. This went on for 4 hours. It was a mistake using this and I hope that in 4 weeks when it is out of her system, she will return to normal. It's only available with a prescription from your veterinarian, so you . My dog is having seizures. I sure hope he makes it! My little Billy Boy had his first visit to the vet and they gave him Simparica Trio. No problem eating. Does anybody know how long this will last? four times. Hello to everyone and I am so sorry we had to meet under these circumstances. Later in the fall I noticed some leg tremors when she squatted. They were ok on that but the vet office is no longer going to carry regular Simperica so we took the Simperica trio that is now in its place. So sad as he was once a happy healthy dog with no prior health issues. Did the tremors ever stop? And how do we get the word out to everyone? Took her to her Vet where I was told she had another tremor. This was January 15 of 2020. Im trying to understand how. It's now March 23, he still has falls but not like at first. I too would like to know how long this symptom lasted in other dogs who experienced the same issue. And yeah he ate today 4 chicken breast and appeared to want it even better. Side effects The contra indication is important to know before you utilize the simparica. I feel like this drug was pushed by my vet tech and veterinarian. He has been low energy since. The vet wont acknowledge it was Simparica although Dolly had no problems with seizures before. The vets and neurologists say it's not simparica trio - but she was perfectly healthy until that dose was given. If you havent already done so, please call the simparica trio phone number and report your dogs symptoms. Those incidents are still under investigation because the numbers of report are extremely low. before i even gave to my dog small doxie i asked the vet about it and they assured me it was safe since she was and i say was a healthy dog. She said to watch for drainage. It has been one week and she has been acting very anxious since. How is your dog doing at this time? Saving money sounds great, right? It's important for your dog to be tested for heartworm disease before starting Simparica Trio (or any other heartworm prevention) because it will not kill adult heartworms and can actually worsen your dog's condition. Glad i held off on the free sample i was given! Get the dog moms and dads in your life something unique this year. Doubtful our dog will be given Simparica again. She has been on it for 6 months. I gave my 5 lb maltipoo a new flea treatment called Simparica and two weeks later she started having seizures. Can someone please tell me if their dogs got better after taking the pill? I only researched it after he started not feeling well, just trusted my vet that this was safe. Wow. This is so awful. It has been 20 days since I gave her the prescribed dose of Simparica. Hope all is well. thank you. Now tremors started. Same here! She is lethargic, unsteady on her feet, doesnt bark at all, showing signs of dimentia. I rescued a dog that had a light case of heartworms. Never happened before. only 7 yrs old and I still considered a puppy b/c of how active he was, we are on 8 days now of the lethargic not eating, goopy eyes - Dr says he has hyernaited disc but I have yet to see the xrays to confirm - blood work came back normail. . Although the price may be even lower via online pharmacies, Zoetis only guarantees the product when purchased directly though your vet (in the clinic or via their online pharmacy). He seems to be out of sorts, staring into space, getting freaked out when he can't see me (I thought he was losing his eyesight). It wasnt even four hours later all four of my dogs were throwing up, lethargic sick as hell didnt think they were gonna make it three pulled out my little Mr. weenie. after a few months of this i decided to go back to Sentinel and Bravecto. Instead, it kills larvae, allowing your dog to avoid infection. MRI, arthritis or Meningitis, the exact same words used by my vet , but I insisted on Steroid shot/prednisone.it has helped! Possible side effects: Vomiting, diarrhea (if these . I put him on boiled chicken & rice and got him calmed down. We just gave the first does to our 11 week old Sheepadoodle puppy yesterday. However, these adverse effects are rarely observed in pets and overall the product is proven to be suitable for all dogs without occurrence of any side effects. Simparica may show slide side effects in a few dogs like tremors, unsteadiness, and/or seizures but else it is Tested and FDA approved suits to 90% of dogs. I won't be letting this go and I'll be actively pursuing recourse from the manufacturer and vet in any way I can. AVOID THIS PILL! He was diagnosed with "Sundowners" . i know this med did this to her , she was on for a year and half , i should never ever have listened to the vet and went with my gut, but again they assured me since she was healthy be very rare she would have side effects smdh and plus been in contract with the makers of this horrible medication they all should be ashamed of themselves!!!!!!!!!!! She had been on the Seresto collar and Tri-Heart for 8 years with no issues. I have 3 other dogs - large breeds that also took 1 dose, but no reaction. Side effects with Simparica are not common. And he was on Comfortis before and did fine. Gave our 23 month old Black Lab. Today March 20 (8 week old) I get a message saying the puppy ate one of these pills that was for the bigger dog she already owned. I thought maybe my dog had a bladder infection or got into something that upset her gut. I am a physical therapist, and acquired Sadie to serve as a Therapy Dog in our clinic. The most common side effects of Simparica in dogs are vomiting and diarrhea. Nobody knows what causes it or makes one dog recover and another not. Gave my dog Charlie Simparica yesterday now he is shaking and panting really bad. Trifexis and Simparica are available only with a prescription from your veterinarian. He loves the taste of Simparica Trio and it's like a treat for him. Just our own personal experience but I won't get burned again! Although he didnt continue throwing up and was fine otherwise, he was still outside 12 hours later eating grass. This Tuesday the 17th I had given my dog simparica trio for 27lbs dose. Or has it been too many doses ? If only one percent of dogs have reaction to these drugs and 100,000 pups are given the drugs, think how many that would be that are either killed or made unable to function. Thank u Fox I have good news I did get 2 additional in house potassium test done and they both came back normal. Available in six weight categories: 2.8-5.5 lbs, 5.6-11 lbs, 11.1-22.0 lbs, 22.1-40 lbs, 44.1-88.0 lbs and 88.1-132 lbs. My 14 year old, 3.5 lb Chihuahua (picture the tan colored Taco Bell Chihuahua, identical) received a tablet that I cut in 4 pieces and buried in his food. If I still lived in the city, I would probably use the garlic because the previous GS never had any issues and lived a long time. Also what are you looking at giving your dog as a seizure medication?? The innovative formula disrupts gamma-aminobutyric acid (GABA) and glutamate receptors, which both play a role in nerve transmissions. Ive spent over $3,000 on vet bills for at least four visits to the ER and follow up lab work including X-rays. Thannks !! That was when I lived in Fort Lauderdale. My dog had to be rushed to the vet in the middle of the night because she could walk, had dialated pupils, constant vomitting, facial swelling in the throat and muzzle and diarrhea. His neck felt swollen and he was panting heavily gasping for air. https://photos.app.goo.gl/GbP8UmDNBAxJ1m4g8 I feel like we are just waiting for him to pass now. He scratched at them which made it worse. I assume it's getting out of his system. I hope and pray for no long term affects. iI hope she will not have any other problems. I'm so sorry. I gave my six-year-old dog SIM perica because the combo guard was on back order. Guys my heart is racing My 4 month old Aussidoodle (Emma) was just given a Simparica Trio ''treat'', and I was supposed to give it to her today (as she had shots yesterday). He ran bloods and sent her home with Keppra three times a day, after two weeks she is now down to twice a day. Still waiting on the vet and waiting to talk to ASPCA poison control. I do believe it caused her blindness. So scary. I am terrified--wish I would of seen this sooner. If your dog or cat experiences any adverse event while using an isoxazoline product, first consult your veterinarian. He had ONE dose that evening and completely lost his appetite within a couple days. After reading theses comments I started looking into SIMPARICA TRIO. He would come out of it when I shook him, so I didn't think anything of it at the time. I have every intention of calling and filing a complaint. Has anyone recently started simpatico trio on their fur baby and noticed any kidney problems? Will not use this again and will warn others. The company's thinking must be the profits outweigh the loses from any lawsuits lost its important to note that the law treats animals as property and the fix value of a dog is quite small and limited. Vet thinks it may be Addision disease and wants to test for it. The personality change is what has me most concerned too. We hope this will solve our problems and he can live a healthy and happy life. all my dogs were prescribed and my eldest dog has had a strange reaction hives all over his body, panting, restless started same night he took the pill but has had the product on previous occasions with no side effects but this time he had a that reaction,had to administer meticam for the pain and antihistamines for the hives - he is still not right after 4 days and my other dog louie has always suffered from seizures since a pup vet say possible epilepsy - managed without medication at present and I do always try to avoid medication with him as they always make his seizures worse - I am so angry for not researching this further before .. Contrary to the statement in that same above article "The results are fatal for fleas and ticks but safe for mammals such as your dog." At the same time, it opens glutamate-gated channels, which adds to the flood of nerve communications. Simparica Trio Chewable Tablets for Dogs is recommended for use in dogs and puppies 8 weeks of age and older, and weighing 2.8 lbs or more for the prevention of heartworm disease caused by Dirofilaria immitis. It all depends, sadly. Buy Simparica Trio Chewable Tablet for Dogs, 44.1-88 lbs, (Green Box), 12 Chewable Tablets (12-mos. A day and a half after her 3rd dose of Simparica she had a really bad gran mal seizure and we though she was going to die. After about 35 days he was back to normal. The whole packet is going in the bin !! I shall be looking for a natural product from now on, k and g pet supplies on amazon do a good mange spray so hopefully that will be all they need from now on. Will it get worse Will he get better? . like she wants me to fix it. I put water with electrolytes by his cage & food . This sounds so scary. She never did that before! Nexgard can cause lethargy and a loss of appetite in dogs. Went to a different vet, within minutes he found a large mass on my Poms abdomen. The seizure has finally stopped and he seems to be sleeping peacefully. Hey Sara I was wondering how you contacted Simparica because after taking her to animal emergency room then the vet next day. I hope yours is an isolated incident! Dogs Naturally Market is a good source to check out. Two months no flare up no more scabs and loosing hair. I feel like she's been an experiment to make others money. My 10 year old Standard Poodle had one dose of Simparica and had seizures two weeks later, which was yesterday. But im 99% sure the simparica is what caused it. I am so sad to read what is happening to some pets. All content contained in this article is sourced from public sources or the manufacturer. The diarrhea and vomiting went away after a few days but the cough has lingered for over a month now even with treatment. First it was a fake guess of Lyme (she's from Texas where Lyme is not) disease diagnosis and $1200 wasted. I have to turn him around and lead him away. I hope there will be a class action lawsuit but most importantly that the word get out to stop this medication from harming another life. Even with what she has been through we have to wait until Dec 1st to see the Neurologist as there is only one in the State of Maine. I found a warning from the FDA about the potential for neurologic adverse events in dogs and cats when treated with drugs that are in the isoxazoline class. Simparica Trio should be used with caution in dogs with a history of seizures. Simparica Trio comes with a customer satisfaction guarantee: Zoetis will cover some or all vet expenses should your dog develop heartworm disease, Lyme disease, a flea infestation, hookworms, or roundworms. Revolution has been around decades with less incidents of animal reactions. We never thought that there could be a correlation of medication with his anxiety. Sorry but keeping it caged due to a suspected side effect is is uncalled for. Its now about May 16th 2021. Another call to vet asking for an appt - seems like an an emergency now? Called vet and was advised chicken and rice by tech - vet did not come to the phone even tho I asked to speak to her twice. I've tried Gatorade and Ginger ale but he only drank a little. Also vets needs to tell the truth!!! Benefits: Each tablet provides a full month of protection against fleas and ticks. Moxidectin was first approved by the FDA in 1997 for the prevention of heartworm disease in dogs. Sarolanerstarts fighting fleas within three hours and begins to kill ticks after 8 hoursincluding the lone star tick, black-legged tick, brown dog tick, American dog tick, and Gulf Coast tick. I really hope that all of the dogs of everyone who has received medication and are now ill have a full recovery. We contacted the company using the phone number supplied in the under in the box and shared our experience with the new drug. Hi, Id like to thank all the contributors to this thread and Im so very sorry for the pain you and your pets have undergone. Over two weeks later she still can not walk properly. In such cases, please visit the veterinarian as soon as possible. Initially I noticed minor tremors and twitching when he slept or was just relaxing. Our 6 year old, 66# Treeing Walker Coon Hound baby has been taking Simparica for about two years. He has been on just Simparica with no problems. Been also very lethargic not wanting to get out of bed. She's finally resting at home, but still not able to walk, run, eat, etc. She still has her appetite at the moment. Maybe? We talked with Zoetis (the manufacturer of Simparica) after the FDA's announcement to get some concrete numbers on the frequency of these adverse reactions. Another one of our dogs also has had several episodes of suddenly crying as if she is in great pain and also began within a week of administering the poison (please don't call this a medicine, it is a poison intended to kill fleas and other bugs and in this case it can also kill your doggie). Got a new GS when the old one died. Hi, we did a spinal tap and MRI, its not viral or bacterial, its called steroid responsive meningitis which essentially is the meninges inflaming on their own, but if you look in this thread youll see others reporting similar symptoms/diagnosis so I do think Simparica trio triggered/caused it. Your vet should be able to answer any questions related to side effects, precautions, or special care for your dog. Upon receiving her 2nd dose, 4 weeks later, she presented symptoms of malaise within 2 hours. It was 11:30 pm . Im at the 30 day mark from giving him the symparico and he no longer has pain but they want to continue him on a 4-6 months treatment of steroids as if its meningitis but I dont love the idea because the steroids have side effects too. Wont use again. He started having skin issues that the vet said were allergic reactions probably due to environmental things. The vet said the simparica didn't cause the disease but it could have been the link that pushed him into the Crisis. Im now scared half to death. Next day, he was suddenly 1000% worse, would not touch food, could not move. Simparica has a low incidence of seizures but still the FDA made the company include the warning. Get practical pet health tips, articles, and insights from our veterinary community delivered weekly to your inbox. They would clear up after a round of antibiotics but would return the next month. Vet says not to go back to Any brand oral flea/tick meds, so well be using Frontline drops on her shoulders from now on. Head bobbling and hind legs unable to support her - as if she were really drunk. By Tuesday evening symptoms came back worse. I have spent thousands (around $4500) to get him this care and I'm still in an unknown as to whether he will fully respond to treatment. Overview. Im beside myself with guilt and fear. He's a 1 1/2 y.o. Were there any other conditions? Hes been on it for six months. Im certain that its the simparica. I was blaming the tremors in his back legs on the fact that he has had both ACLs repaired. I removed it immediately She just tested positive for Lyme's. Please think these things through before subjecting your pet to internal insecticides. Finally resting at home, but still not able to walk, run, eat, etc cage! 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